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Research Paper | Oral Pathology and Microbiology | India | Volume 4 Issue 11, November 2015

Evaluation of Mast Cells, Vascular Luminal Diameter and Epithelial Thickness in Different Grades of Oral Submucous Fibrosis

Dr Sabu Paul ^[4] | Dr Pramod Philip Mathews

Abstract: Aim: To evaluate the implication of mast cell role in the changes of the vascular luminal diameter along with the epithelial thickness of oral submucous fibrosis. Materials And Methods: Patients with histological diagnosis of oral submucousfibrosis and healthy volunteers comprised the study group. The parameters, epithelial thickness and vascular luminal diameter were quantified using image analysis software. Enumeration of intact and degranulated mast cells were performed with the microscope fitted with a calibrated mechanical stage. Statistics: ANOVA was used to test the equality of means between epithelial thickness, vascular luminal diameter and mast cell count. Pearson?s correlation was used to find the correlation between these variables. Results: The present study shows an inverse relation between epithelial thickness and vascular luminal diameter and the result was found to be statistically significant. The mast cell count showed a decreasing trend as the disease progresses. Conclusion: The study concluded that there was significant correlation between epithelial thickness and vascular luminal diameter, which is in agreement that hypoxia due to the increased fibrosis induces dilatation of vessels. Although presence of mast cells plays a significant role in early oral submucous fibrosis, their role in modulation of angiogenesis in later stages may be insignificant.

Keywords: oral submucous fibrosis, image analysis, epithelial thickness, vascular luminal diameter, mast cells

Edition: Volume 4 Issue 11, November 2015,

Pages: 2551 - 2554