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Research Paper | Chemistry | India | Volume 5 Issue 1, January 2016
A Novel Approach to the Synthesis of Some Naphthofuran Derivatives Bearing Polar Substituents for Studying their Antimicrobial Activity
Dr. Amar Singh Yadav [2] | Kaman Singh
Abstract: -Naphthol on reaction with N- (hydroxyalkyl) -arylamides/ imides (1) in ethanol containing catalytic amount of conc. HCl furnishes N- (2-hydroxy-naphthalen-1-yl-alkyl) -arylamides/ imides (2) which on treatment with benzoin in dioxan containing triethylamine (TEA) affords N- (2, 3- diphenyl-naphtho [2, 3-b] furan-9-yl-alkyl) - arylamides/ imides (3). Compounds 3 have been evaluated for their antimicrobial activity involving four bacterial and six fungal strains.
Keywords: Antimicrobial resistance, nitrofurazone, amidoalkylation
Edition: Volume 5 Issue 1, January 2016,
Pages: 606 - 608
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