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Research Paper | Medicine Science | India | Volume 7 Issue 1, January 2018 | Rating: 6.7 / 10
A Comparative Evaluation of Dexmedetomidine and Clonidine as an Adjuvant to Ropivacaine in Epidural Anaesthesia for Intraoperative and Postoperative Sedation and Analgesia
Dr. Vijeta Khandelwal, Dr. Khushboo Malav, Dr. S.P. Chittora, Dr. Gajanand Dhaked
Abstract: Background - This prospective randomized double blind study was carried out to evaluate and compare the effect of dexmedetomidine and clonidine as an adjuvant to ropivacaine in epidural anaesthesia. Method - Ninety patients (ASA grade I and II), were randomly allocated into three groups of 30 patients in each. Group A (R) received 17 ml of 0.75 % ropivacaine + 2ml saline (control), group B (RD) received dexmedetomidine 1.5g/kg in 2ml+ 17 ml of 0.75 % ropivacaine and group C (RC) received clonidine 2g/kg in 2ml+17 ml of 0.75 % ropivacaine in epidural anaesthesia. All three groups were evaluated in terms of onset of analgesia, duration of analgesia, motor block, sedation and any untoward side effects. Results - Onset of analgesia (sensory block) was earlier in group B (8.132.02 mins) than group A (12.133.37 mins) and group C (9.862.84 mins) (p
Keywords: Dexmedetomidine, Clonidine, Ropivacaine, Alpha 2 agonist, Epidural anaesthesia
Edition: Volume 7 Issue 1, January 2018,
Pages: 1085 - 1090