Rate the Article: Design, Synthesis and Evaluation of New Diclofenac Derivative More Selective COX2 Inhibitor, IJSR, Call for Papers, Online Journal
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064

Downloads: 120 | Views: 288

Research Paper | Pharmaceutical Science | Iraq | Volume 7 Issue 11, November 2018 | Rating: 6.6 / 10


Design, Synthesis and Evaluation of New Diclofenac Derivative More Selective COX2 Inhibitor

Yahya S. Yaseen, Muthana S. Farhan, Ammar A. Fadhil, Maysam A. Hussein, Nada N. AL-Shawi


Abstract: New series of 2-Azetidinone (I-IV) were synthesized, the structure of these new derivatives were confirmed using spectral methods starting from diclofenac sodium. We prepared diclofenac acid by using hydrochloric acid, then converted to amide ester by using thionyl chloride, then converted to hydrazide by using hydrazine hydrate 99.5 %, then a Schiff bases were synthesized using different aromatic aldehydes in ethanol, and the final compounds were obtained by cyclocondensation using chloroacetylechloride. The synthesis of the designed compounds has been successfully achieved. Purity and characterization were confirmed by determination of physical properties (melting points & Rf values), FT-IR spectroscopy and CHN analysis.


Keywords: Diclofenac, Schiff base, 2-Azetidinone, antibacterial activity, aldehyde


Edition: Volume 7 Issue 11, November 2018,


Pages: 1394 - 1401



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