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Research Paper | Medicine | India | Volume 12 Issue 4, April 2023 | Rating: 5 / 10
Recurrent Acute Pancreatitis as the First Presentation of Primary Hyperparathyroidism
Dr. Nidhi Bhutada, Dr. Shubham Sabne
Abstract: Pancreatitis is a common non - bacterial inflammatory disease caused by activation, interstitial liberation and autodigestion of pancreas by its own enzymes. Common causes of acute pancreatitis are gall stones, alcohol, drugs, trauma, viral infections and hypertriglyceridemia. Much is known about the causes of pancreatitis but huge experimental data available about understanding of its pathogenesis is still incomplete. Hypercalcemia as a cause of pancreatitis is rarely reported. Hypercalcemia is usually the result of Primary hyperparathyroidism (PHPT) and the most common cause of PHPT is parathyroid adenoma. It is thought that the increased calcium concentration in pancreatic juice resulting from hypercalcemia may prematurely activate proteases. Mutations in different genes have been proposed as well to justify why only some patients with primary hyperparathyroidism and hypercalcemia develop acute pancreatitis. Here we present a case of recurrent acute pancreatitis resulting from hypercalcemia in a 26 - year - old male. Hyperparathyroidism was suspected when despite severe pancreatitis calcium level remained high and parathormone level was grossly raised.
Keywords: Primary hyperparathyroidism, Acute Pancreatitis, Hypercalcaemia, Renal calculi, Spleenic calcification
Edition: Volume 12 Issue 4, April 2023,
Pages: 1843 - 1844