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Analysis Study Research Paper | Obstetrics and Gynecology | India | Volume 12 Issue 6, June 2023 | Rating: 5 / 10
Oral Nifedipine and Intravenous Labetalol for Hypertensive Emergencies in Pregnancy: A Comparative Study
Dr. Ankita Gahlot [2] | Dr. Jyotsna Vyas | Dr. Ekta K [2]
Abstract: Background: Hypertensive emergency in pregnancy is defined as persistent acute - onset, severe hypertension (Systolic BP >160 mmHg or diastolic BP >110 mmHg or both) in the setting of preeclampsia or eclampsia. Objective: Compare safety and efficacy of oral nifedipine and intravenous labetalol for acute blood pressure control in hypertensive emergencies of pregnancy Study design: a randomised comparative hospital based study conducted in Department of Obstetrics and Gynaecology, SMS Medical College, Jaipur from April 2021 to Nov 2021. Sample: 80 women with hypertensive emergencies. Method: Divided into 2 groups of 40 each. Nifedipine grp received 10mg tab every 20 min till maximum of 5 doses and labetalol grp was given iv labetalol in escalating doses of 20, 40, 40, 80 and 80mg every 20 min till a target BP was achieved. Main outcome measures: Better treatment for Hypertensive emergencies of pregnancy. Results: In our study, mean time required to achieve target BP in nifedipine and labetalol group was 45+14.84 and 54+18.22 minutes (p value 0.018) respectively. Mean decrease in SBP after treatment was 59 ? 21.1 mmHg in Nifedipine group as compared to 42.25 ? 22.7 mmHg in Labetalol (p - value = 0.001). Also the mean decrease in DBP in nifedipine group was 37.5 ? 11.49 mmHg as compared to 27.75 ? 15.34 mmHg in labetalol group (p - value = 0.001). There were no significant differences between side effects and fetomaternal outcome. Conclusion: Oral Nifedipine controls hypertension more rapidly and with fewer doses and is as safe as iv Labetalol.
Keywords: nifedipine, labetalol, hypertensive emergency
Edition: Volume 12 Issue 6, June 2023,
Pages: 267 - 270