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Research Paper | Medicine | India | Volume 13 Issue 1, January 2024 | Rating: 4.9 / 10
A Cross - Sectional Study for Lipid Profile as an Indicator of Severity in Cirrhosis of Liver
Dr. Viresh Verma | Dr. Anil Kumar Kem [4]
Abstract: Background: A number of scoring systems, such as the Child - Pugh score and Model for End - Stage Liver Disease (MELD) score, are available to evaluate the severity of cirrhosis. The altered lipid profile can serve as a predictive biomarker of cirrhosis because the liver is the primary organ involved in the conversion of excess carbohydrates into lipids. We evaluated the lipid profile anomalies in liver cirrhosis patients and found a correlation between them and the severity of the disease. Materials and methods: This study examines the lipid profile of patients admitted to a tertiary care centre in Uttar Pradesh as a potential indicator of the severity of liver cirrhosis. After cirrhosis was confirmed by a thorough investigation, all eligible patients with the disease had their fasting serum lipid profile evaluated. Serum low - density lipoprotein (LDL) and very - low - density lipoprotein (VLDL) were calculated using the Friedwald formula, whereas total serum cholesterol, triglycerides (TGL), and high - density lipoprotein (HDL) were measured directly. Results: The study included 110 patients in total. Seventy - two (65.45%) of them were men. The most frequent causes of cirrhosis among them were alcohol (82, 74.5%), hepatitis B (9, 8.1%), and non alcoholic steato hepatitis (NASH) (7, 6.3%). For increasing severity as determined by the Child - Pugh score and MELD score, there is a discernible dose - response association (decreasing trend) in the lipid levels. Furthermore, in comparison to the corresponding groups, patients with as cites or spontaneous bacterial peritonitis had considerably lower cholesterol, LDL, and HDL levels. Conclusion: This study observed that there is a significant reduction in levels of lipid profile parameters like serum total cholesterol, LDL, VLDL, TGL, and HDL in patients with cirrhosis as the severity increases. Further formulation of the scoring system in association with a preexisting scoring system may provide a better assessment of patients? prognosis in view of morbidity and mortality. We recommend it is necessary to assess the fasting lipid profile in all patients with cirrhosis and prognosticate their disease progression.
Keywords: Cirrhosis, Hepatitis, Non alcoholic Steatohepatitis, Lipid profile
Edition: Volume 13 Issue 1, January 2024,
Pages: 1214 - 1216