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Case Studies | Medical Science | India | Volume 12 Issue 1, January 2023 | Rating: 4.3 / 10
Acute Transverse Myelitis as a Paraneoplastic Manifestation in Chronic Myeloid Leukaemia on Imatinib Therapy: A Case Report
Dr. Vaibhav Balakrishna Gowda
Abstract: We present a rare case of transverse myelitis as a paraneoplastic manifestation in chronic myeloid leukemia on imatinib therapy. A 45 year old male presented with 5 day history of both lower limb weakness progressing to paresthesia and urinary retention and constipation. Patient is a known case of cml on imatinib therapy. On examination patient is having flaccid paraplegia with bilateral plantar extensor with sensory level at T8.MRI spine revealed hyperintense signal extending from D8 to conus medullaris. CSF showed mild pleocytosis with increased protein. Patient was started on injectable methylprednisolone and patient improved subsequently. Transverse myelitis is a rare paraneoplastic manifestation of systemic malignancy. Hence all cases of transverse myelitis should undergo paraneoplastic workup.
Keywords: chronic myeloid leukemia, paraneoplastic syndrome, transverse myelitis, Imatinib
Edition: Volume 12 Issue 1, January 2023,
Pages: 223 - 224