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Research Paper | Chemistry | India | Volume 12 Issue 11, November 2023 | Rating: 5.3 / 10
An Emergent Synthesis of Novel Isoxazolidines Via 1,3-Dipolar Cycloaddition of ?-Cinnamic Aryl-N-Aryl Nitrone with ?-Nitrostyrene and IT?S Antibacterial Activities
M. R. Bhamuni | S. R. Jayapradha
Abstract: A new series of isoxazolidine derivatives are synthesized with good yields by 1,3-dipolar cycloaddition reaction between newly synthesized nitrones and an efficient dipolarophile ?-nitrostyrene. The ?-Cinnamic aryl-N-aryl nitrone and ?-nitrostyrene as a novel class of dipolarophile has been synthesized in shortened reaction time to get an excellent yield. This specific nitrone and dipolarophiles are refluxed in the presence of toluene in a conventional method to give a five membered heterocyclic compound namely isoxazolidine. The structure of all the synthesized isoxazolidines are characterized by FT-IR, Uv-vis spectroscopy, 1H and 13C NMR spectra. The cycloadducts-isoxazolidines formed also exhibit a biological activities.
Keywords: Isoxazolidine, 1,3-dipolar cycloaddition, Cinnamaldehyde, Nitrone, Dipolarophile
Edition: Volume 12 Issue 11, November 2023,
Pages: 700 - 707