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Research Paper | Health and Medical Sciences | India | Volume 12 Issue 11, November 2023 | Rating: 4.9 / 10
Autoimmune Hemolytic Anemia after Allogeneic Stem Cell Transplantation: Single Centre Experience
Nikita Yadav, Shweta Sharma, Rachna Narain, Priya Marwah
Abstract: Purpose: Auto immune hemolyticanemia (AIHA) post allogeneic hematopoetic stem cell transplantation (HSCT) is a rare and still poorly understood complication. Detailed work on this complication are needed due to lack of prospective trials. Methods: This is a retrospective cohort study of 7 patients with AIHA after HSCT in a tertiary care Medical College Hospital from 2012 - 2023. Results: The overall incidence of AIHA after allogeneic HSCT was 3.93%. All transplants were performed for non - malignant condition.57.1 % of the patients who developed post transplant AIHA did not have any ABO Incompatibility.42.8% patients who developed post transplant AIHA had concurrent GVHD. All patients responded well to oral corticosteroids. Conclusion: Though a rare complication, post transplant AIHA is seen more commonly in patients undergoing HSCT for non - malignant conditions. Multi centric trials are the need of the day to understand this rare yet morbid post transplant complication.
Keywords: Autoimmune hemolyticanemia, allogeneic HSCT, ABO incompatibilty, Graft versus Host Disease
Edition: Volume 12 Issue 11, November 2023,
Pages: 1948 - 1951