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Case Studies | Psychiatry | Ireland | Volume 12 Issue 12, December 2023 | Rating: 5.9 / 10
Asymptomatic CK Increase in Patient with Neuroleptic Sensitivity after the Development of Neuroleptic Malignant Syndrome
Vojnic Barisic J | Grummel M | Kusen I | Quinlan M
Abstract: Neuroleptic malignant syndrome NMS is a life-threatening condition associated with the use of antipsychotic medications, primarily resulting from rapid dosage changes or abrupt discontinuation. This article explores the risk factors, clinical presentation, diagnosis, and treatment of NMS, with a focus on a unique case involving a 41-year-old male with paranoid schizophrenia. The patient experienced NMS after discontinuing Clozapine, with an unexplained recurrence 14 days later. Genetic factors and pharmacogenomics are discussed as potential contributors to NMS susceptibility. The importance of early recognition and monitoring in atypical NMS presentations is emphasized, given the high mortality rate associated with this condition. This case highlights the need for further research and guidelines in patients prone to medication side effects and those at risk of NMS, aiming for more individualized and safer prescribing practices.
Keywords: Neuroleptic malignant syndrome, antipsychotic medications, schizophrenia, genetic factors, pharmacogenomics
Edition: Volume 12 Issue 12, December 2023,
Pages: 928 - 931