Rate the Article: A Randomized Double - Blind Study to Compare the Effect of 0.5% Bupivacaine with Buprenorphine and 0.5% Bupivacaine with Fentanyl in Lower Limb Surgeries under Epidural Anaesthesia, IJSR, Call for Papers, Online Journal
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064

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Comparative Studies | Anaesthesiology | India | Volume 12 Issue 2, February 2023 | Rating: 5.1 / 10


A Randomized Double - Blind Study to Compare the Effect of 0.5% Bupivacaine with Buprenorphine and 0.5% Bupivacaine with Fentanyl in Lower Limb Surgeries under Epidural Anaesthesia

Arpita Bhargava, Pratheev E, Ritushree Sharma, Rajan Nanda


Abstract: Background: For lower abdominal and lower limb surgeries, regional anaesthesia is preferred over General anaesthesia. Epidural anaesthesia is useful as a primary anaesthetic, but most commonly, it is used as a pain management adjuvant. We evaluated compare the effect of 0.5% bupivacaine with buprenorphine and 0.5% bupivacaine with fentanyl in lower limb surgeries under epidural anaesthesia. Material and methods: A randomized double blind study was conducted in 90 patients of either gender divided in three groups. In Group A (n=30) patients were received 0.5% bupivacaine 15 ml with 0.5 ml Buprenorphine with 0.5 ml and normal saline made to a total 16 ml. in Group B (n=30) patients were received 0.5% bupivacaine 15 ml with 1 ml fentanyl and in Group C (n=30) patients were received 0.5% bupivacaine 15 ml with 1 ml normal saline for epidural anaesthesia. These groups were compared using one - way analysis of variance (ONE ?WAY ANOVA) and difference between the groups compared using unpaired T - Test. Results: Duration for analgesia was more with epidural Buprenorphine. Conclusion: We concluded that epidural Buprenorphine is better in providing prolonged satisfactory postoperative analgesia as compared to Fentanyl.


Keywords: Isobaric Bupivacaine, Buprenorphine, Fentanyl, Epidural


Edition: Volume 12 Issue 2, February 2023,


Pages: 1372 - 1377



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