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Research Paper | Biomedical Sciences | India | Volume 12 Issue 2, February 2023 | Rating: 5.1 / 10
Synthesis and Study of Anti Fungal Activity of 1, 4-Benzothiazines Derivatives
Kumar Gaurav Jain, C. P. Singh, Sandeep Kumar
Abstract: Imines forms an important class of heterocyclic compounds such as1,4-Benzothiazine and its derivatives which shows wide range of biological activities such as antimicrobial, antifungal etc. Therefore, some new benzothiazine derivatives were synthesized by using benzalaniline and substituted benzalanilines with sulphene, generated in situ from methane sulphonyl chloride and triethylaminehydroxylchloride, as a starting material. The synthesized 1,4-benzothiazines (Ia -Va) were tested in vitro for their antifungal activity against Alternaria alternate, Curvularialunata, Fusarium oxysporumand Myrothecium roridum by employing the standard technique of spore germination inhibition at various concertation?s. Some of the compounds have shown promising antifungal activity against test fungi.
Keywords: 1, 4- Benzothiazine(1,4-BT), Antifungal activity, Antimicrobial activity, SGI, Benzalaniline?s Compound
Edition: Volume 12 Issue 2, February 2023,
Pages: 1504 - 1506