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Research Paper | Genetics | India | Volume 12 Issue 5, May 2023 | Rating: 4.4 / 10
Influence of Intra Familial Relationship on Hypertension among the Population of Sivgangai, Tamil Nadu
Jepa Chandra Mohan | Dhivya P [2]
Abstract: Consanguineous marriage is one of the customary practices in South India. It is a type of inbreeding among the populations who share a common ancestor. First cousin marriages were the most common practice among South Indian population. Genetically, it was proven that consanguinity increases the chance of transmitting identical recessive gene, which leads to the possibility of incurable hereditary diseases. The present study was undertaken to determine the rate of consanguinity and its effect on high blood pressure among the selected Sivagangai population. High blood pressure is a common hereditary disorder in South India. It increases the chance of various cardiovascular impairments. In the current study, a total of 1062 families were selected and interviewed about their consanguinity and their prevalence of high blood pressure. Among the total population, 34.18% were consanguineous and 65.81% were non-consanguineous marriages in the parent generation, and 8.47% were consanguineous and 91.52% were non-consanguineous in the grandparent generation. The incidence of high blood pressure is higher in consanguineous populations (60%) than non-consanguineous populations (40%). This showed that congenital abnormalities were double-fold higher among inbreeding populations than out breeding populations. The genes associated with high blood pressure are CYP11B (11-beta hydroxylase gene) on chromosome 8q CYP11B2 (aldosterone synthase gene) on 8p, WNK1, WNK4 (lysine-deficient protein kinase 1 and 4 genes) on 12p, KLHL3 on 5q, CUL3 (cullin 3 gene) on 2q, SCNN1B, SCNN1G (Amilorid-sensitive sodium channel, beta and gamma subunit gene encoding two subunits of the ENaC sodium channel) on 16p, CYP17A1 (steroid 17-hydroxylase/17, 20 lyase gene) on 10q, HSD11B2 (11-beta-hydroxy steroid dehydrogenase 2 gene) on 16q, NR3C2 (mineralocorticoid receptor gene)on 4q and KCNJ5 (potassium inwardly rectifying channel gene, subfamily J, member 5)on 11q. Genetic factors associated with this disease were due to the occurrence and transmission of lethal identical recessive genes. The preference for out breeding is the only way to remove the lethal genes from the gene pool of human population.
Keywords: Inbreeding, homo-zygosity, Mineralocorticoids, Endogamy
Edition: Volume 12 Issue 5, May 2023,
Pages: 2152 - 2156