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Research Paper | Medical Science | India | Volume 13 Issue 11, November 2024 | Rating: 5.6 / 10
Study of Lipid Profile in Patients of Ischemic Heart Diseases in Tertiary Care Hospital, Barabanki
Dr. Mirza Adil Beig, Dr. Mayank Garg, Dr. Ranjay Gupta
Abstract: Background: The impact of lipid profile factors on the prognosis of CHD patients remains debatable, despite the established role of these factors in the etiology of CVD. Therefore, it is crucial to comprehend the correlation between abnormal lipid profiles and ischemic heart disease patients in order to close the knowledge gap regarding the link between dyslipidemia and this population. Objectives: To study the lipid profile changes in patients of ischemic heart disease. Methods: This was 18 month hospital based cross sectional study conducted by Dept. of Medicine; Dr. KNS Memorial Institute of Medical Science, barabanki. The patients of ischemic heart disease (Group1) and Normal patients without ischemic heart disease (Group 2), who visited to medicine OPD of Dr KNS Memorial Institute of Medical Sciences, Barabanki were enrolled in our study. Lipid profile estimation was performed using a semi - auto mated biochemistry analyzer Total cholesterol, triglycerides and HDL cholesterol was estimated. LDL cholesterol and VLDL cholesterol was calculated using Friedewald's formula. For qualitative data analysis Chi square test was applied, and for quantitative data analysis t - test and ANOVA tests was applied for significance. If P value <0.05, it was considered significant. Results: A total of 120 participants were enrolled based on eligibility criteria. Among them 60 participants were the patients of ischemic heart disease (IHD). and 60 participants were age and sex matched healthy control. Among 60 cases; 40% were diagnosed with acute coronary syndrome; 31.67% were diagnosed with congestive heart failure; and 28.33% were diagnosed with chronic stable angina. Among 60 cases of IHD - most of them complained about chest pain (34.70%) and sweating (35.30%) followed by breathlessness (30%); palpitation (26%); headache (28.70%); dizziness (25.30%); restlessness (26%); and others (14.70%).13.33% cases were asymptomatic. On applying multiple logistic regression analysis; it was found that hypertension (78.33% v/s 28.33%; p<0.001); diabetes (63.33% v/s 30%; p<0.001); family h/o AMI (55% v/s 21.67%; p<0.001) and h/o smoking (63.33% v/s 20%; p<0.001) increase the odds of occurring IHD. But the h/o alcohol was not associated as risk of IHD (29.30% v/s 26.70%; p=0.716). The mean value of total cholesterol (167.30 v/s 149.93; p=0.032); triglyceride (159.49 v/s 129.19; p=0.026); LDL (108.95 v/s 91.02; p=0.04) was significantly higher in IHD patients as compared to Controls. But mean VLDL (27.22 v/s 28.93; p=0.463) and HDL (39.49 v/s 38.44; p=0.729) were found comparable between the groups. Conclusion: Persons with IHD had aberrant lipid profile levels, such as higher total cholesterol, LDL cholesterol, and triglyceride levels, in comparison to the control group. The study concluded that even during follow - up, it is vital to evaluate the lipid profile and their ratio for these individuals since these parameters lead to the development of atherogenic myocardial infarction and other coronary issues.
Keywords: Lipid Profile, Acute Coronary Syndrome, Atherogensis
Edition: Volume 13 Issue 11, November 2024,
Pages: 1654 - 1659