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Comparative Studies | Anaesthesiology | India | Volume 13 Issue 12, December 2024 | Rating: 5.3 / 10
A Randomized Double Blind Comparative Study of Two Different Doses of Intrathecal Dexmedetomidine 5 mcg and 10 mcg AS Adjuvant to 0.5% Levobupivacaine Heavy (12.5mg) in Spinal Anaesthesia for Infraumbilical Surgery
Dr. Neelam Singh, Dr. Shobhit Singh, Dr. Suneel Kumar
Abstract: Introduction: Subarachnoid block is most commonly used for infraumbilical surgeries. Various adjuvants like fentanyl, clonidine and dexmedetomidine have been used for prolongation of anaesthetic effect of intrathecal levobupivacaine heavy. Different doses of dexmedetomidine have shown varying results. Objectives: To compare two different doses of dexmedetomidine 5 mcg and 10 mcg as an adjuvant to intrathecal levobupivacaine heavy 12.5mg in terms of onset and duration of sensory and motor block, hemodynamic effects and adverse effects in patients undergoing infraumbilical surgeries. Methods: Prospective, randomized, double blind study of 120 patients divided into three equal groups (40 each) named Group L, D5 and D10, of age between 18 - 60 years with ASA grade I & II undergoing infraumbilical surgeries under spinal anaesthesia was done. Intrathecal 0.5% levobupivacaine heavy 12.5mg (2.5ml), intrathecal 0.5% levobupivacaine heavy 12.5mg (2.5ml) with 5mcg dexmedetomidine and intrathecal 0.5% levobupivacaine heavy 12.5mg (2.5ml) with 10mcg dexmedetomidine was given to each patient of Group L, D5 and D10 respectively. Onset and duration of sensory and motor block was noted and hemodynamic parameters were compared between these groups. Results: The mean time of onset of sensory and motor block was lesser in group D10 as compared to group D5 and group L (p<0.001). Duration of sensory and motor block was longer in group D10 as compared to group D5 and group L (p<0.001). Incidence of bradycardia and hypotension was seen in group D10. Conclusion: In the present study it was found that addition of dexmedetomidine to intrathecal levobupivacaine heavy leads to early onset of sensory and motor block as well as prolongation of their duration in a dose dependent manner.
Keywords: Levobupivacaine heavy; Dexmedetomidine; Intrathecal
Edition: Volume 13 Issue 12, December 2024,
Pages: 307 - 313