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Comparative Studies | Anaesthesiology | India | Volume 13 Issue 12, December 2024 | Rating: 4.9 / 10
Haemodynamic Effects - A Comparison Between Succinylcholine (1.5mg/kg) and Rocuonium Bromide (0.9mg/kg) for Rapid Sequence Induction of Anaesthesia
Dr. Jyoti Raje, Dr. Shankar Hari Priya, Dr. Rajiv Kumar Singh, Dr. Anil Kumar Singh
Abstract: Background and Aims: Rapid Sequence Induction (RSI) is a critical technique used to secure the airway in patients at risk of aspiration, involving preoxygenation, cricoid pressure, and rapid intubation. Succinylcholine and Rocuronium are two muscle relaxants frequently used in RSI. This study aims to compare the haemodynamic effects in adult patients undergoing elective surgery. Methods: A total of 60 patients, aged 18-60 years, with ASA Grade I and II physical status, who were undergoing various elective surgical procedures, were enrolled. Patients were randomly divided into two groups of 30 each. Group I received Succinylcholine (1.5 mg/kg), and Group II received Rocuronium (0.9 mg/kg) as neuromuscular blocking agents for intubation. Hemodynamic monitors were noted. Result: Both Succinylcholine and Rocuronium caused a statistically significant increase in heart rate (HR) and mean arterial pressure (MAP) immediately after intubation due to the stress response (p < 0.01), which then normalized within five minutes. Both agents were effective for securing the airway with minimal adverse effects, and the transient haemodynamic changes observed were primarily attributed to the intubation process rather than the neuromuscular blocking agents themselves. Oxygen saturation remained stable across both groups, with no significant differences observed (p > 0.05). Conclusion: We conclude that both Succinylcholine and Rocuronium observed transient haemodynamic changes primarily attributed to the intubation process rather than the neuromuscular blocking agents.
Keywords: rapid sequence induction, rocuronium bromide, succinylcholine, intubation, laryngoscopy
Edition: Volume 13 Issue 12, December 2024,
Pages: 969 - 971