Downloads: 1 | Views: 88 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1
Research Paper | Biochemistry | India | Volume 13 Issue 5, May 2024 | Rating: 5.2 / 10
Serum Levels of Adenosine Deaminase and Insulin in Type 2 Diabetes Mellitus
Yengkhom Upen Singh | Laithangbam Rosyka [2] | Laikangbam Shaini [3] | Moirangthem Sinorita Devi | Nikkita Laishram | Ongchu Phom
Abstract: Introduction: Diabetes mellitus is one of the most leading endocrinological disorder characterized by chronic hyperglycemia, metabolic abnormalities and long term complications. It is one of the most common non - communicable disease globally and fifth leading cause of death in most developed countries. Prevention of diabetes and its associated burden, primarily cardiovascular morbidity and mortality is a major health issue worldwide. Insulin is an important polypeptide hormone that regulate carbohydrate metabolism and with its receptor regulates blood glucose level. Adenosine deaminase (ADA) is a metalloenzyme that catalyses deamination of adenosine and deoxyadenosine to inosine and deoxyinosine respectively. Serum ADA activity is seen to be increased with an increased in insulin resistance in diabetes mellitus patient. Also, the association between serum insulin and ADA in diabetes is not well understood. Objective: To estimate serum adenosine deaminase (ADA), fasting blood sugar level and serum insulin level among cases of type 2 diabetes mellitus and healthy controls and to correlate the levels of ADA and serum insulin levels among cases and controls. Methodology: A case control study, consisting of 80 subjects out of which 40 subjects diagnosed with T2DM and 40 healthy subjects, was carried out in the department of Biochemistry in collaboration with department of Medicine, RIMS, Imphal from October 2017 to January 2019. Serum ADA level, serum insulin and fasting blood glucose levels were measured. Result: The mean ? SD of serum insulin level in cases were significantly higher in case group (18.09?5.554 ?IU/ml) when compared to control group (9.09 ?2.509?IU/ml). Also the mean serum ADA level in diabetic cases was higher in case group (38.97?8.853 U/L) and lower in the control group (20.05?5.309U/L). There was positive correlation between serum ADA and serum insulin level and was statistically significant as p < 0.05. Conclusion: Serum adenosine deaminase and serum insulin were significantly increased in type 2 diabetes mellitus than normal controls and correlated with each other.
Keywords: Insulin, Adenosine deaminase, Diabetes mellitus
Edition: Volume 13 Issue 5, May 2024,
Pages: 260 - 264