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Informative Article | Oncology Science | India | Volume 13 Issue 8, August 2024 | Rating: 4.8 / 10
Chemotherapy-Induced Neurotoxicity
Jassim Rahiman K
Abstract: Chemotherapy-induced neurotoxicity is a significant challenge in cancer treatment affecting 30 -40% of patients and manifesting as both central and peripheral nervous system complications. Common neurotoxic agents include platinum-based compounds, taxanes, vinca alkaloids, proteasome inhibitors, and immunomodulatory drugs. These agents can lead to a range of symptoms including peripheral neuropathy, cognitive dysfunction and severe neuropsychiatric effects, which can limit the dose of chemotherapy and duration compromising treatment efficacy. The mechanisms underlying chemotherapy-induced neurotoxicity involve oxidative stress, mitochondrial dysfunction, DNA damage, microtubule disruption, and inflammatory processes. Current strategies for managing neurotoxicity include dose modification, drug substitution, and the use of neuroprotective agents like calcium and magnesium infusions, glutathione, and duloxetine. However, these approaches are not always effective and research is ongoing to develop more targeted therapies. Future directions in this field include the identification of biomarkers for susceptibility to neurotoxicity, the development of less neurotoxic therapeutic agents and the integration of rehabilitation and supportive care to maintain patient quality of life. Collaborative efforts between healthcare professionals are essential to mitigating the impact of neurotoxicity on cancer treatment outcomes. This review explores the mechanisms underlying chemotherapy induced neurotoxicity, current management strategies and potential future directions in research aimed at reducing the neurotoxic burden on cancer patients.
Keywords: Neurotoxicity, Chemotherapy, Peripheral Neuropathy, Cancer Treatment, Neuroprotective Agents
Edition: Volume 13 Issue 8, August 2024,
Pages: 1250 - 1254