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Narrative Review | Oncology Science | India | Volume 13 Issue 8, August 2024 | Rating: 5.8 / 10
Understanding Glandular Cell Carcinoma of the Appendix: Pathology, Diagnosis, and Management Strategies
Rathin Joshi | Abiy Tereda | Saheli Kansara | Kirtan Patel [2]
Abstract: Appendiceal adenocarcinoma, a rare malignancy originating from glandular cells, poses significant challenges in diagnosis and treatment due to its rarity and complex presentation. This review provides an indepth exploration of the pathology, diagnostic challenges, and management strategies for this malignancy. Despite its location within the gastrointestinal tract, the appendix's exact function remains elusive, though research suggests roles in microbiota regulation, endocrine cell production, and immune modulation. Epidemiologically, adenocarcinoma of the appendix is exceptionally rare, with a slight increase in prevalence observed recently, predominantly affecting individuals in their fifth to seventh decades, with gender-specific patterns evident in subtypes. Histologically, it manifests through glandular formations, cytological abnormalities, tissue infiltration, and mucin secretion, defining distinct subtypes with varying clinical implications. Surgical excision remains the cornerstone of treatment, supplemented by chemotherapy and emerging targeted therapies. The review also delves into the molecular mechanisms, including genetic mutations, that underlie the development of glandular cell carcinoma of the appendix.
Keywords: Appendiceal adenocarcinoma, glandular cell carcinoma, appendix cancer, pathology, management strategies
Edition: Volume 13 Issue 8, August 2024,
Pages: 1731 - 1738