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Research Paper | Public Health | India | Volume 13 Issue 10, October 2024 | Rating: 4.1 / 10
Exploring the Therapeutic Potential of Ribozymes in Cancer Treatment: A Comprehensive Review
Rhea Solomon
Abstract: Ribozymes, RNA molecules with catalytic properties, offer promising therapeutic potential in cancer treatment. This review examines the role of ribozymes in combating Kaposis sarcoma associated herpesvirus KSHV and glioblastoma, highlighting their unique stability and resilience. We discuss the combination of ribozyme therapy with traditional chemotherapy, as evidenced in clinical trials targeting the flt2 receptor. This paper underscores the significance of ribozymes in cancer therapy and the importance of public health policies for equitable technology distribution. This article aims to explore the therapeutic potential of ribozymes in cancer treatment, focusing on their application against Kaposis sarcoma associated herpesvirus KSHV and glioblastoma, while also addressing the implications for public health policy. Ribozymes, RNA-protein complexes where the RNA exhibits catalytic activity, have existed for eons and have remained remarkably consistent throughout evolution. These molecules challenge the traditional view that enzymes are solely composed of proteins, suggesting they have numerous unexplored roles. Our review delves into the nature of ribozymes, exploring the various types that have persisted over time. Notably, ribozymes have been linked to cancer, which offer promising therapeutic potential. We discuss how ribozymes combat Kaposi?s sarcoma-associated herpesvirus (KSHC) infection and their therapeutic effects on glioblastomas. Cancer, one of the most debilitating diseases affecting humanity, presents treatment challenges due to therapies' loss of effectiveness over time. However, the inherent stability and unique properties of ribozymes make them resilient to alteration. This study is significant as it highlights the novel role of ribozymes in cancer therapy, offering new avenues for treatment, particularly in overcoming the limitations of traditional therapies. Ribozymes have been predicted to cure many infectious diseases including cancer. A combination of chemotherapy and ribozyme against the flt-2 receptor has been found to cure cancer in phase II clinical trials. Multiple studies mentioned above clearly highlight the novel role of ribozymes in curing cancer. We believe that using ribozymes can provide a cure for this dreadful problem in all low, middle, and high-income group countries. Ribozymes are available in all organisms be it prokaryotes and eukaryotes. It is their extraction that might become a monetary issue but the implementation of policies in place will help different income groups work together and allocate resources to make this world cancer-free. Public health policies that help in the appropriate distribution of technology and products from one stratum to another will help in detecting early cases and curing them when they are not that widespread. Using ribozymes for early detection will be easy as these are quite specific and are able to detect small changes too. By summarizing data from various research organizations, our review addresses one of the most pressing public health issues, proposing ribozymes as a promising avenue for future therapies.
Keywords: Ribozymes, Cancer Therapy, RNA Protein Complexes, Glioblastoma, KSHV
Edition: Volume 13 Issue 10, October 2024,
Pages: 1105 - 1113