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Research Paper | Biology | India | Volume 13 Issue 9, September 2024 | Rating: 4.9 / 10
Gut - Brain Axis: A Driver in Neurodegenerative Disease
Reeshika Bhatia
Abstract: The gut - brain axis (GBA) represents a critical communication network linking the gastrointestinal and central nervous systems, influencing physiological and psychological health. This paper explores the multifaceted role of the GBA in the onset and progression of neurodegenerative diseases, such as Alzheimer's and Parkinson's. It delves into how alterations in the gut microbiome may contribute to neurodegenerative processes, potentially serving as early biomarkers for these conditions. Furthermore, the study examines the interplay between genetic factors and gut microbiota, highlighting the potential for therapeutic interventions targeting the GBA to mitigate disease progression. By synthesizing historical perspectives, and current research, the paper identifies significant gaps in understanding the mechanistic pathways involved, particularly the causal relationships between gut dysbiosis and neurodegeneration. Ultimately, this work aims to enhance early diagnostic methods and therapeutic strategies by emphasizing the importance of gut health in neurodegenerative disease management.
Keywords: The gut - brain axis, neurodegenerative diseases, gut microbiome, dysbiosis, Alzheimer's disease, Parkinson's disease, biomarkers, therapeutic interventions, probiotics, and neuroinflammation
Edition: Volume 13 Issue 9, September 2024,
Pages: 1091 - 1100