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Student Project | Health and Medical Sciences | India | Volume 14 Issue 3, March 2025 | Rating: 5.6 / 10
Case Report: A Tumor with a Twist: Navigation the Complexities of Sinonasal Glomangiopericytoma
Dr. Arpitha H. C., Dr. Sudhir M Naik
Abstract: Background: Sinonasal glomangiopericytoma (SGP) is a rare, low-grade mesenchymal tumor arising from pericytes of Zimmerman, primarily affecting the nasal cavity and paranasal sinuses. It commonly presents with nasal obstruction and recurrent epistaxis, making diagnosis challenging. Due to its histological resemblance to other vascular tumors, immunohistochemistry (IHC) is essential for confirmation. Surgical excision is the mainstay of treatment, with a low risk of metastasis but potential for local recurrence, necessitating long-term follow-up. Case report: A 50-year-old female presented with recurrent right-sided nasal bleeding for one year, worsening over the past three days. Nasal endoscopy revealed a vascular mass, and CT imaging showed a soft tissue lesion extending into the nasopharynx. The patient underwent endoscopic surgical excision. Histopathology confirmed SGP, supported by IHC findings-positive for SMA and ?-catenin, negative for CD34, ERG1, CD31, S100, CK, and D240. Postoperative recovery was uneventful, with no recurrence observed. Conclusion: Sinonasal glomangiopericytoma is an uncommon vascular tumor requiring a high index of suspicion. Accurate diagnosis relies on clinical, radiological, and histopathological correlation. Endoscopic surgical resection is the preferred treatment, with careful follow-up to monitor recurrence. Increasing awareness and case reports will aid in optimizing diagnosis and management.
Keywords: Sinonasal glomangiopericytoma, mesenchymal tumor, nasal cavity, paranasal sinuses, nasal obstruction, epistaxis, immunohistochemistry, endoscopic surgical excision, histopathology, smooth muscle actin, ?-catenin, local recurrence, vascular tumor, differential diagnosis, follow-up monitoring
Edition: Volume 14 Issue 3, March 2025,
Pages: 1239 - 1241