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Survey Paper | Medicine Science | Albania | Volume 3 Issue 12, December 2014 | Rating: 6.1 / 10
Do Patients With Thalassaemia Major Manifest Endocrine Complications? Can We Solve Them?
Manika Kreka [2] | Eleni Nastas [2] | Xhensila Prendushi | Irena Qendro | Bledi Kreka | Vjollca Shpata
Abstract: It is estimated that endocrine abnormalities are present in thalasaemic patients. Despite the early diagnosis and the optimal iron chelation therapy, there are still important in many clinical situations like: delayed sexual maturation and impaired fertility. The aim of the study was to assess the correlation of ferritin level and growth and sexual hormones of organism in inidividuals with thalassaemia. A statistically negative correlation was found between ferritin level at the end of third year of treatment with Deferasirox and testosterone, (r=-0.6 p
Keywords: thalassaemia, iron, deferasirox, delayed puberty, hypogonadism
Edition: Volume 3 Issue 12, December 2014,
Pages: 379 - 381