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Research Paper | Biochemistry Science | India | Volume 4 Issue 4, April 2015 | Rating: 6.7 / 10
In Vitro α- Amylase Inhibitory Activity and GC- MS Analysis of Petrea volubilis
Parul Sharma [4] | Rekha Vijayvergia
Abstract: One of the therapeutic approaches which involve decreasing hyperglycemia aims at inhibiting the enzyme -amylase. The aim of the present study was to investigate the in vitro anti-diabetic activity of the methanolic extract of Petrea volubilis. The assay results showed that the extract exhibit the dose-dependent increase in inhibitory effect on alpha-amylase enzyme upto 81.57 % with IC 50 value 24.750.294 g/ml. GC- MS analysis of root sample suggests that 1, 2-Benzenedicarboxylic acid, mono (2- ethylhexyl) ester compound may be responsible to decrease hyperglycemia. This study shows that the roots of Petrea volubilis were most effective in inhibiting -amylase, thereby proving to be potential anti-diabetic agents.
Keywords: amylase enzyme, GC- MS analysis, IC 50 value, Petrea volubilis
Edition: Volume 4 Issue 4, April 2015,
Pages: 190 - 194