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Research Paper | Dental Science | India | Volume 6 Issue 1, January 2017
DNA Sequencing for AXIN 2 (SNP 7591 and 7224837) Gene Polymorphisms in Non-Syndromic Cleft Lip and/or Cleft Palate in the Local Population
Vishnuvardhan V | Manjunath Hegde | Dinesh M. R | R. M. Dharma
Abstract: Introduction- The aim of this study was to evaluate the association of AXIN2 gene variants rs 7591 and rs 7224837 with non-syndromic cleft lip and palate. Materials and Methods Blood samples of 30 subjects with NSCLP and 30 unrelated controls were used for the study. The extracted DNA samples were subjected to Polymerase chain reaction in which amplification of the selected gene segments was done, later these amplified products were subjected to DNA sequencing. Results-This study suggests that the likelihood of Non-syndromic cleft lip and palate is higher in subjects having TT (p<0.001) & AT (p=0.03) genotype for AXIN2 gene variant rs7591 and AG (p=0.01) genotype for AXIN2 gene variant rs7224837. Conclusion The result suggests that AXIN2 gene variant rs7591 and AXIN2 gene variant rs7224837 can be considered as genetic markers for Non syndromic cleft lip and palate in local population
Keywords: Non-syndromic Cleft Lip and Palate, AXIN2, AXIN2 gene variant rs7591 and AXIN2 gene variant rs7224837
Edition: Volume 6 Issue 1, January 2017,
Pages: 1 - 6
Similar Articles with Keyword 'Cleft'
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Comparative Studies, Dental Science, India, Volume 10 Issue 12, December 2021
Pages: 1002 - 1004Comparative Assessment of Sagittal Skeletal Discrepancy in Patients with Bilateral Cleft Lip and Palate - A Cephalometric Study
Arihant Golchha | Pragati Jain | Shashi Ahirwar | Rishabh Golchha | Shivani Deshmukh
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Research Paper, Dental Science, India, Volume 7 Issue 11, November 2018
Pages: 1837 - 1855Perceived Knowledge Regarding the Specialty of Referral in Oro-Facial Conditions among Health Care Professionals
Dr Prakhar Mongia | Dr Suresh Babu P [3] | Dr Naveen Kumar Jain [3]