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Research Paper | Medical Surgical | India | Volume 9 Issue 1, January 2020

To Compare and Evaluate the Efficacy of Esmolol and Labetalol in Attenuating Pressor Response to Laryngoscopy & Tracheal Intubation during General Anesthesia

Dr. T. S. Vinil Kumar | Dr. Kiran Kumar Gera | Dr. T. Surya Sree ^[3]

Abstract: BACKGROUND: Laryngoscopy and endotracheal intubation are associated with increased sympathomimetic response. Aim: To compare and evaluate the efficiency of Esmolol and Labetalol in attenuating the haemodynamic response to Direct laryngoscopy and endotracheal intubation. MATERIALS & METHODS: It is a Prospective, randomised, double-blind study in 50 patients of ASA grade I or II aged between 2060 years of either sex who were scheduled for elective surgeries under general anaesthesia and divided into two groups (each group containing 25 patients). Group L (Labetalol): patients received injection Labetalol, 0.25 mg/kg IV bolus diluted to 10 ml with 0.9 % saline. Group E (Esmolol): patients received injection Esmolol 0.5 mg/kg IV bolus diluted to 10 ml with 0.9 % saline. All the selected patients are subjected to the same anaesthesia technique. HR, SBP, DBP and MAP were recorded before intubation, and then during intubation 0 minute, 1 min, 3 min, 5 min of intubation. RESULTS AND CONCLUSION: In lower doses, Labetalol provides better protection than Esmolol in attenuating the sympathomimetic response to laryngoscopy and intubation

Keywords: Esmolol, Labetalol, Pressor response, General anaesthesia

Edition: Volume 9 Issue 1, January 2020,

Pages: 712 - 714

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