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Research Paper | Chemistry | India | Volume 5 Issue 5, May 2016
Synthesis and In Vitro Evaluation of Anticancer activity of Mannich Bases of Benzimidazole Derivatives
Pranika Kaur [2] | Sharad Wakode
Abstract: Benzimidazole moiety is an important class of heterocycles used for synthesis of medicinal compounds. Mannich bases of Benzimidazole were synthesized. The structures were identified by determining their melting points, TLC, IR spectral analysis and 1HNMR spectrum. Anticancer activity was performed in vitrofor screening of synthesised compounds by Sulfordamine B (SRB) assay. Cytotoxicity of compounds was evaluated for lung, prostrate, colon and breast tissue. Compound VIII a and VIII bshowed 100 % cytotoxicity against colon cancer. The compound VI c showed 89 % cytotoxicity against lung cancer. Against prostate cancer compound VIII a resulted in 73 % cytotoxicity. The compound VIII a and VI a showed 94 %, 93 % cytotoxicity respectively against breast cancer.
Keywords: Mannich base, Heterocyclic, Benzimidazole, Anticancer activity, Cytotoxicity, Genotoxicity
Edition: Volume 5 Issue 5, May 2016,
Pages: 1096 - 1099
Similar Articles with Keyword 'Mannich base'
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Research Paper, Chemistry, India, Volume 6 Issue 3, March 2017
Pages: 1867 - 1874Improved Process for the Preparation of Halo Substituted Mannich Bases of Substituted Benzimidazoles
Satyanarayana Punna | I. E. Chakravarthy | M. Aswartha Umakantha Reddy
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Research Paper, Chemistry, India, Volume 4 Issue 1, January 2015
Pages: 2624 - 2628Synthesis, Characterization and Evaluation of Antimicrobial Activity of Various Mannich Bases of Isoindoledione Derivatives
Chakrawarti Prasun | S. R. Wakode [2]