International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


Downloads: 114 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper | Medicine Science | India | Volume 4 Issue 4, April 2015


Azathioprine as a Steroid Sparing Agent in Recalcitrant Type 2 Reaction

Dr. Raju Chaudhary | Dr. Khushbu Modi


Abstract: Introduction Severe recalcitrant Type 2 Leprosy reaction (ENL) is recalcitrant to conventional therapy & characterized by ulcerative necrotic skin lesions, known as Erythema Nodosum Necroticans and required long term systemic glucocorticoid therapy which leads to serious complications. To prevent serious side effects of ENL one should consider steroid sparing agents. Azathioprine is generally well tolerated and has a favourable therapeutic index compared with other traditional immunosuppressant. In our study, severe ENL patients recalcitrant to conventional therapy were successfully managed with Azathioprine monotherapy. Objective - To evaluate Azathioprine as a steroid sparing agent. - To prevent serious side effects of Glucocorticoids. - To prevent systemic complications of severe Type 2 leprosy reaction. Methods Total 14 cases of severe recalcitrant T2R were enrolled in study. We started Azathioprine average 100 mg per day in all 14 patients for total period of 12 months along with oral Prednisolone and anti leprosy treatment (MB Adult Pack). Clinical & laboratory evaluations were done at baseline (0), 3, 6, 9 & 12th month. Results At the end of 12 months, only one patient showed recurrence of ENL & remaining 13 patients (92.85 %) were absolutely fine & they didn-t require any immunosuppressive. We found serious side effects of Glucocorticoids before treatment which were prevented at the completion of study, as early as at 6 months & serious necrotic skin lesions before treatment were healed with Azathioprine & Prednisolone combination. In our study we found 92.85 % success rate in Azathioprine treatment in severe recalcitrant T2R. Conclusion Azathioprine is a good adjuvant immunosuppressive drug in the control of recalcitrant Type 2 reactions, and especially as a GCS sparing agent with minimum side effects.


Keywords: Recalcitrant Type 2 Leprosy Reaction, Azathioprine, Steroid Sparing Agent


Edition: Volume 4 Issue 4, April 2015,


Pages: 1885 - 1890


How to Download this Article?

You Need to Register Your Email Address Before You Can Download the Article PDF


How to Cite this Article?

Dr. Raju Chaudhary, Dr. Khushbu Modi, "Azathioprine as a Steroid Sparing Agent in Recalcitrant Type 2 Reaction", International Journal of Science and Research (IJSR), Volume 4 Issue 4, April 2015, pp. 1885-1890, https://www.ijsr.net/get_abstract.php?paper_id=SUB153490

Similar Articles with Keyword 'Type'

Downloads: 0

Review Papers, Medicine Science, Brazil, Volume 11 Issue 11, November 2022

Pages: 1088 - 1092

Revisiting the Roles of IL-17 in Colorectal Cancer

Larissa Volpini Cardoso | Gustavo Gabriel Zonaro | Barbara Nunes da Silva | Giulia Frederico | Vinicius Barbieri Lanfredi | Leandro Minatel Vidal de Negreiros | Sergio Luiz Pinheiro | Raquel Franco Leal | Giovanna Rosa Degasperi

Share this Article

Downloads: 1

Research Paper, Medicine Science, Albania, Volume 4 Issue 3, March 2015

Pages: 2210 - 2212

Risk Factors in Heart Attack

Edi Smajlaj [2] | Sabit Brokaj [2]

Share this Article
Top