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Research Paper | Physiology Science | Nigeria | Volume 3 Issue 3, March 2014 | Rating: 6.8 / 10
Long Term Administration of Cannabis sativa Reduces Food, Water Intake and Body Weight in Mice
V. E. Okon, A. O. Obembe, V. U. Nna, E. E. Osim
Abstract: The effects of long-term administration of Cannabis sativa on food, water intake and body weight was studied in mice. Twenty seven albino mice (male and female) were used for the experiment. They were assigned randomly into three groups (control, low dose and high dose) containing nine (9) mice each. Group I (the control group) was given 10ml/kg of normal saline. Group II (The low dose group) was administered 10mg/kg/day of Cannabis sativa; Group III (high dose group) was administered 20mg/kg/day Cannabis sativa. Administration was done orally for a period of 4 weeks during which food and water intake were measured daily. Their body weight was taken every two days. The amount of food taken was weighed, subtracted from original weight and recorded. The results showed that the mean daily food intake were significantly lower (P<0.001) for the Cannabis treated groups compared to control; while mean water intake was significantly lower (P<0.01) and (P<0.001) for low dose and high dose groups respectively compared to control. The Cannabis treated groups also had a significantly lower (P<0.001) body weight than their control. In conclusion, long term administration of Cannabis sativa decreases food, water intake and body weight gain.
Keywords: body weight, Cannabis sativa, food intake, mice, water intake
Edition: Volume 3 Issue 3, March 2014
Pages: 389 - 392