Downloads: 117 | Views: 306 | Weekly Hits: ⮙2 | Monthly Hits: ⮙2
Research Paper | Biology | India | Volume 3 Issue 6, June 2014 | Popularity: 6.7 / 10
Comparative Evaluation of Immune Protective Effect of Melatonin and Boerhaavia diffusa in Lymphoid Tissues of Park's Strain Mice against Antibiotic Induced Oxidative Stress
Somenath Ghosh, Shweta Sharma, Abhinav Joshi, Chandana Haldar
Abstract: Boerhaavia diffusa; a native plant of India; is an antioxidant. Aims were to compare; physiological efficacy of root and stem extracts of B. diffusa either alone or in combination with melatonin on improvement of immune and antioxidant status of mice under normal or antibiotic induced stress. Parks strain mice were grouped into control (Con) ; melatonin (Mel) ; ethanolic root (BRE) and stem (BSE) extract treated alone and in combination with melatonin (BRE+Mel and BSE+Mel). Further; mice were grouped into control (Con) ; ampicillin treated (AMP) ; and BRE; BSE and Mel pre-treated groups receiving AMP (AMP+BSE; AMP+BRE; AMP+Mel). Blood and spleens of all the groups were collected and processed for Total Leukocyte Count (TLC) ; % Stimulation Ratio ( %SR) of splenocytes; estimations of Total Anti-oxidant Status (TAS) ; TBARS; Super Oxide Dismutase (SOD) and apoptosis analysis (Et-Br Assay). Significant increase in TLC; % SR of splenocytes; TAS level; SOD and significant decrease in apoptotic index of splenocytes and TBARS level in BSE+Mel; BRE+Mel; AMP+Mel than Con; Mel; BRE; BSE; AMP; AMP+BSE and AMP+BRE treatments were noted. Conclusively; melatonin in combination with root and stem extracts of B. diffusa improved immune and antioxidant status. Melatonin pre-treatment alone ameliorates ampicillin induced immune compromised condition and oxidative stress.
Keywords: Antibiotic, Antioxidant, Boerhaavia, Melatonin, Mice
Edition: Volume 3 Issue 6, June 2014
Pages: 1111 - 1120
Make Sure to Disable the Pop-Up Blocker of Web Browser
Similar Articles
Downloads: 108
Research Paper, Biology, Iraq, Volume 6 Issue 12, December 2017
Pages: 1399 - 1403Effect of the Mutagenic Agents and NaCl on the Activity of Antioxidant Enzymes in Two Genotypes of Iraqi Rice (Oryza sativa L.)
Rasha K. Mohammed
Downloads: 48
Research Paper, Biology, India, Volume 4 Issue 2, February 2015
Pages: 1304 - 1306Effect of Cd++ On Catalase Activity on Air Breathing Fresh Water Teleost Fish Heteropneustes fossilis (Bloch)
Anupama Shrivastava, Sabiha Naz
Downloads: 105
Research Paper, Biology, Iran, Volume 3 Issue 5, May 2014
Pages: 954 - 958Antioxidant Activity and Total Phenolic Content in Two Alga Species from the Persian Gulf in Bushehr Province; Iran
Abdolali Movahedinia, Mohsen Heydari
Downloads: 105
Research Paper, Biology, India, Volume 4 Issue 9, September 2015
Pages: 2089 - 2092Study on Ethnic Manipuri Cuisine And Estimation of Phytonutrients in Centella Asiatica (Brain Food)
Anjusana Khundrakpam, S Sivakami
Downloads: 107
Research Paper, Biology, Malaysia, Volume 6 Issue 2, February 2017
Pages: 2088 - 2096Evaluation of the Anti-Diabetic Activity of a Novel Formulation of Functional Foods in Streptozotocin-Induced Balb/c Diabetic Mice Model
Asmahan Alamin A. Krayem, Moklesur Rahman Sarker