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Research Paper | Botany | India | Volume 3 Issue 6, June 2014 | Rating: 6.8 / 10
Invitroantidiabetic Activity of Nerolidol: An Active Compound Isolated From Alpinia Calcarata
Silvy Mathew [2] | S. John Britto
Abstract: Diabetes mellitus is a well known clinical ailment leading to various late complications like retinopathy; neuropathy; nephropathy etc. The results of the work indicate that the nerolidol characterized from Alpinia calcarata possessed considerable invitro antidiabetic activity. Alpinia calcarata Roscoe is known for its therapeutical use in Indian traditional medicine. It is therefore essential to investigate the inherent profile of phytocompounds which confer therapeutic value. This analysis focuses on the antidiabetic potential of the selected species. Synthetic inhibitor often causes side effect such as abdominal pain; diarrhoea etc. Nerolidol seems promising for the development of a phytomedicine for Diabetes mellitus. It has been found that the IC 50 of Acarbose (standard) is 220g/ml and while in the case of nerolidol it exhibits much more activity ie; IC 50 is 130g/ml.
Keywords: Diabetes mellitus, nerolidol, Alpha amylase inhibition, Acarbose, hyperglycemia, IC50
Edition: Volume 3 Issue 6, June 2014,
Pages: 2712 - 2715