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Research Paper | Pharmaceutical Science | Nigeria | Volume 10 Issue 3, March 2021 | Popularity: 6.8 / 10

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Utilization and Anti Bacterial Assessment of Chrysophyllumalbidum Seed Oil on Skin Cream Formulation

Ordu J I, Nwachi R C

Abstract: Seed crops are vital sources of oils and the plant-derived oils from underutilized seed crops such as Chrysophyllumalbidum could be useful in cosmetic and pharmaceutical applications especially for the formulation of creams, soaps, emulsions, ointments and for wound disinfection and management. Three batches of creams were, formulated following the melt emulsification method of oil and aqueous phase. Batch A consist of (extracted C. albidum seed oil alone), batch B (olive oil used alone) and batch C (extracted oil and olive oil combined in a 1: 1 ratio), then the physiochemical and anti-bacterial properties determined and compared with gentamicin a reference standard. Dilution tests of the formulated creams reveals an oil in water type of emulsion with pH values: batch A (6.850.08), batch B (7.130.04) and batch C (8.340.11). The formulated creams were smooth and non-greasy in appearance with viscosity (Cp) at 28.7OC of batch A (1.130.02) batch B (3.040.04) and batch C (4.020.03) There was no phase separation upon centrifugation at 3000rpm but on thermal analysis at 60OC, creams of batch A liquefied within 35 minutes, batch B- 79 minutes and batch C- 28 minutes. Anti-microbial activities reveals high susceptibility of test organisms (Staph aureus, P. aerugnosa, E. coli, P. vulgaris, K. pneumonia and B. cereus) to formulated creams with that of batch C being comparable to gentamicin followed by batch A then batch B.

Keywords: Chrysophyllumalbidum, oil, Cream, utilization, anti- bacteria

Edition: Volume 10 Issue 3, March 2021

Pages: 343 - 348

DOI: https://www.doi.org/10.21275/25121805

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