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Research Paper | Chemistry | India | Volume 5 Issue 8, August 2016 | Popularity: 6.6 / 10

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Simultaneous Determination and Validation of Olmesartan Medoximil and Metoprolol Tartarate by Analytical Technique RP-HPLC

J. Sandya Rani, N. Devanna, J. Mamatha

Abstract: A rapid reverse phase high performance liquid chromatography method has been developed and validated for the determination of Olmesartan medoximil and metaprolol tartarate in combined tablet dosage form. Isocratic technique was adopted using C18 column (1504.6mm, 5 XTerra) with a phosphate buffer [pH 2.8] as a mobile phase and the flow rate of 0.5ml/min at UV wavelength 284nm. The Rt values was found to be 3.624 & 5.178min and the above drugs with a run time of 10min. Various chromatographic parameters including Specificity, Linearity, Accuracy, Precision, LOQ, LOD, Robustness, System suitability have been evaluated. The present investigation was validated as per ICH guidelines for the drugs.

Keywords: ICH, Validation, Olmesartan Medoximil, Metaprolol Tartarate, RP-HPLC

Edition: Volume 5 Issue 8, August 2016

Pages: 1557 - 1561

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