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Research Paper | Chemistry | Saudi Arabia | Volume 6 Issue 3, March 2017 | Rating: 6.1 / 10
Synthesis and Biological Activity of Some New ?- Lactame Derivatives
F. A. Yassin | Amal F. Seliem [2] | B. E. Bayomy | H. M. Hawsawi
Abstract: Methyl 5-amino- 3- methylthio-1- phenyl-pyrazole -4- carboxylate 1 was reacted with different aldehydes namely, benzaldehyde, anisaldehyde, p- nitrobenzaldehyde, p-chlorobenzaldehyde and p-bromobenzaldehyde in the presence of glacial acetic acid at refluxed temperature afforded the corresponding Schiff- bases 2 (a-e), which on reaction with each of chloroacetyl chloride and thioglycolic acid gave the corresponding -lactam derivatives 3 (a-e) and thiazolidines 4 (a-e) respectively. N-alkylation of pyrazole derivative 6 was achieved by reaction with chloroacetyl amino acetophenone 5 in refluxing toluene, while the reaction of purified semicarbazone 7 with each of thionyl chloride and selenium dioxide gave the corresponding1, 2, 3- thiadiazole 8 and 1, 2, 3-selenadiazole 9 derivatives. The antibacterial and antifungal activities of some synthesized compounds have been discussed.
Keywords: Pyrazole, thiazolidine, semicarbazone, -lactam, thiadiazole, selenadiazole, Schiff- bases, antibacterial and antifungal activities
Edition: Volume 6 Issue 3, March 2017,
Pages: 914 - 919