Downloads: 129 | Views: 302

Review Papers | Immunology | India | Volume 6 Issue 4, April 2017 | Popularity: 6.1 / 10

Role of Mannose Binding Lectin and their associated Srine Protease in innate immunity

Pankaj Kumar Patel, Bavita Kohli, Krishnan Hajela

Abstract: Mannose binding Lectin (MBL) is a key pattern recognition receptor molecule, found in invertebrates to higher vertebrates, MBL initiates various immune and immunomodulatory responses on binding with the pathogen associated molecular patterns (PAMPs). MBL recognizes a wide variety of viruses, bacteria, protozoa, fungi and cell debris opsonizing and clearing them either by opsonophagocytosis or activating complement pathway through MASP-1/2 mediated cleavage of complement components C4 and C2, thus generating the C3 convertase C4bC2b. A new insight on the responses, their mechanism and role of MBL associated serine proteases are discussed in the review.

Keywords: Mannose binding Lectin, Complement pathway, Pentraxin, Lectin pathway, MASP

Edition: Volume 6 Issue 4, April 2017

Pages: 620 - 625

Make Sure to Disable the Pop-Up Blocker of Web Browser

Text copied to Clipboard!

Pankaj Kumar Patel, Bavita Kohli, Krishnan Hajela, "Role of Mannose Binding Lectin and their associated Srine Protease in innate immunity", International Journal of Science and Research (IJSR), Volume 6 Issue 4, April 2017, pp. 620-625, URL: https://www.ijsr.net/getabstract.php?paperid=ART20172170, DOI: https://www.doi.org/10.21275/ART20172170

Downloads: 313 | Views: 493

Immunology, India, Volume 8 Issue 3, March 2019

Pages: 423 - 428

Immunotherapy for Cancer

Sanjivani Pathak, Sunanda Patil

Downloads: 177 | Views: 411

Immunology, India, Volume 9 Issue 4, April 2020

Pages: 663 - 671

Story of the Most Triggering Issue of the Globe: 2019 Novel Coronavirus (COVID-19)

Yerusha Nuthalapati, Vanaja Sri Doddi

Downloads: 150 | Views: 459

Immunology, United States of America, Volume 6 Issue 10, October 2017

Pages: 24 - 30

Research Proposal to See if Possible HCV Epitopes Can be Used to Make a Recombinant Vaccine

Jonas Tyler Doran

Downloads: 147 | Views: 347

Immunology, India, Volume 9 Issue 4, April 2020

Pages: 481 - 486

A Study of the Discard Rate of Blood and Blood Products and their Management at Tertiary Care Centre

Dr. Neha Singh

Downloads: 144 | Views: 344

Immunology, Egypt, Volume 7 Issue 6, June 2018

Pages: 66 - 72

Comparative Immunological Study between the Efficacy of Bivalent Inactivated H5N1-ND and Baculovirus Expressed H5N1-ND Inactivated Vaccine (BEST) in Broiler Chickens

Raheel I.A.R., Abed A.H., Hassan K.E., Orabi A.