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Review Papers | Biochemistry | India | Volume 6 Issue 5, May 2017 | Rating: 6.3 / 10
Angiogenic Biomarkers of Dysfunctional Uterine Bleeding
Ketki K [2] | Shailesh Kumar [7]
Abstract: Disturbed endometrial angiogenesis plays a role in the mechanism of Dysfunctional uterine bleeding (DUB). Under hypoxic conditions, Hypoxia inducible factor 1 alpha (HIF-1) rapidly accumulates and activates angiogenic growth factors, receptors and extracellular proteases such as matrix metalloproteinases (MMPs) like MMP-9. Copper influences the production of number of angiogenic factors including HIF-1.
Keywords: Angiogenesis, Dysfunctional uterine bleeding DUB, Hypoxia inducible factor 1 alpha HIF-1, Matrix metalloproteinase -9 MMP-9, Copper, Vascular endothelial growth factor VEGF
Edition: Volume 6 Issue 5, May 2017,
Pages: 2127 - 2132