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Research Paper | Biotechnology | Egypt | Volume 6 Issue 6, June 2017 | Popularity: 6.3 / 10

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Significance of RAGE Marker in Hepatocellular Carcinoma Diagnosis

Samah Mamdouh, Fatma Khorshed, Khaled Hassan, Amr Ageez, Mohamed Seleem

Abstract: Hepatocellular carcinoma (HCC) is considered as one of the most threating cancer type. It is well known as liver cancer. Late diagnosis of HCC may lead to many complications in treatment. Molecular diagnosis is considered the switch key of safe early diagnosis of HCC. RAGE gene is located on the sixth chromosome. It is multi-ligand with multiple functions that can be used in many diseases. This study aims to find the relation between the Expression of RAGE in HCC patients. This study was conducted on 60 samples of tumor and non-tumor tissue samples and HCC serum. RNA was extracted and reverse transcribed then amplified by qRT-PCR. The expression regulated in HCC tissue and HCC serum. This marker can use it as a diagnostic tool that will help in early diagnosis of cancer and better treatment.

Keywords: Hepatocellular carcinoma, RAGE Receptor for advanced glycation end-products, Real time PCR, AGEs advanced glycation end-products

Edition: Volume 6 Issue 6, June 2017

Pages: 2262 - 2265

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