Downloads: 125 | Views: 209

Research Paper | Biotechnology | India | Volume 6 Issue 7, July 2017 | Rating: 6.7 / 10

Evaluation of Antioxidant and Cytotoxic Activity of Decalepis hamiltonii on Hep G2 Cancer Cell Lines

G. Swapna ^[2] | D. Srinivasa Rao | V. Leelavathi

Abstract: Decalepis hamiltonii (Swallow root) belongs to the Asclepediaceae family is a monogenetic climbing shrub endemic to the Deccan peninsula and is used as a culinary spice due to its highly aromatic roots. It is useful as an appetizer, blood purifier, preservative and as a source of bioinsecticide for stored food grains. The present research work aims to identify the enzymatic and non enzymatic antioxidants in animal models, LDH and cytotoxicity activities using HEP G2 cancer cell lines were studied in vivo models to find the anticancer activity of D. hamiltonii methanolic and water extracts. In treated group of animals significant increased levels of enzymatic antioxidants like Superoxide Dismutase, Catalase and Glutathione Peroxidase were observed when compared to toxic group of animals. High concentration of LDH in 320g/ml and 640g/ml were identified as compared to other concentrations like 40g/ml, 80g/ml and 160g/ml. Similarly significant levels of HEP G2 Cell Line viability were predicted at 640g/ml of D. hamiltonii extract. These results might conclude the antioxidant and anticancer activity of D. hamiltonii extract

Keywords: antioxidants, cytotoxicity, hepatic cancer, cell lines

Edition: Volume 6 Issue 7, July 2017,

Pages: 902 - 906