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Research Paper | Oncology Science | Egypt | Volume 6 Issue 2, February 2017 | Popularity: 6.7 / 10
Stem Cell Markers Epithelial Cell Adhesion Molecule (EpCAM) & Cluster of Differentiation (CD44) Expression in Colon Cancer Patients in Relation to Prognosis and Survival
Lobna A. Abdelaziz, Ola A. Megahed, Ola A. Harb, Loay M. Gertallah, Ahmed M. Sallam
Abstract: Background - Worldwide, Colon cancer is the third & the second most common cancer in males & female respectively. Its recurrence, therapy resistance and metastasis remain causes of poor prognosis. The relationship between cancer stem cell (CSC) behavior and chemo-resistance to chemotherapy in patients with colon cancer is a recent point of researches that has taken attention. Identification of CSCs needed specific cell surface markers. CD44 had been the most frequently researched marker for colon CSCs. EpCAM is a cell surface molecule involved in cell to cell adhesion that is expressed in many epithelial carcinomas. Aim of the work - was to evaluate CSC markers EPCAM & CD44 expressions in colon carcinoma correlating their expressions with clinicopathological parameters and patients outcome. Patients and Methods The clinic-pathological correlations between CD44 & EpCAM expressions were assessed in specimens of colon carcinoma embedded in paraffin blocks and were taken from 50 patients, which we followed up for survival and prognosis. Results- CD 44 & EpCam positive expression was significantly correlated with the grade, stage, presence of lymph node, lymphovascular invasion (p<0.001 for all), distant metastases (p<0.001 & = 0.016 respectively), T stage (p= 0.027 & 0.003) respectively. Mean PFS was 27.41.5, median PFS was not reached.3-y PFS was 56 % which was significant with each one of CD44 & EpCam (P<0.001 for both). While, Mean OS was 30.51.2, median OS was not reached, 3-yOS was 64 % with significant association with each one of the markers (P=0.002 for both). Conclusion- we concluded that both CD44 & EpCam positive expressions would be useful poor prognostic markers for colon carcinoma patients.
Keywords: Stem cell markers, CD44, EpCam, colon cancer, survival
Edition: Volume 6 Issue 2, February 2017
Pages: 994 - 1005
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