Downloads: 152 | Views: 349
Research Paper | Pathology | Indonesia | Volume 7 Issue 6, June 2018 | Popularity: 6.8 / 10
Correlation between HIF-1? and CD44 with Radiotherapy Response in Stage IIB-IIIB Cervical Squamous Cell Carcinoma
Farilaila Rayhani, Bethy Suryawathy, Sri Suryanti
Abstract: Cervical cancer is the fourth most commonly malignancy in women worldwide and one of the most common malignancies in Indonesian women. Radiotherapy is one of the therapeutic modalities of cervical carcinoma. On the other hand, radioresistance can cause failure in this treatment. Under certain circumstances, reoxygenation can ensure the successfulness of radiotherapy. HIF-1 and CD44 are proteins markers that play role in hypoxia condition and stemness of cancer cells which has correlation with radiotherapy resistance. The aim of this study is to find the correlation between HIF-1 and CD44 immunoexpression with radiotherapy response in stage IIB-IIIB cervical squamous cell carcinoma. A retrospective case control analysis design has been used in this study, using secondary data of patients stage IIB-IIIB cervical squamous cell carcinoma at the Department of Anatomical Pathology of Dr Hasan Sadikin Hospital, Bandung. There are 64 samples consist of 32 radiotherapy sensitive cases and 32 radiotherapy resistant cases. Immunohistochemical staining of HIF-1 and CD44 were performed to all samples. The result of this study shows a statistically significant correlation between HIF-1 (p=0.0001) and CD44 (p=0.011) immunoexpression with radiotherapy response respectively, with Odd Ratio (OR) 27.35 and 4.78 respectively. In conclusion, radiotherapy response in Cervical squamous cell carcinoma is influenced by hypoxia condition and stem cell status. Immunoexpression of HIF-1 and CD44 can be used to predict radiotherapy response. Increase of HIF-1 and CD44 immunoexpression has a positive correlation with the possibility of radiotherapy resistance.
Keywords: CD44, HIF-1, Cervical Squamous cell carcinoma, Radiotherapy
Edition: Volume 7 Issue 6, June 2018
Pages: 398 - 401
Similar Articles
Downloads: 1
Case Studies, Pathology, India, Volume 11 Issue 1, January 2022
Pages: 553 - 557Recurrent Dermatofibrosarcoma Protuberans - An Institutional Case Series over a Span of 7 Years
Fathima Seles .M
Downloads: 1 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1
Research Paper, Pathology, India, Volume 12 Issue 1, January 2023
Pages: 495 - 498Gliosarcoma: A Rare Variant of Glioblastoma Multiforme: Case Report
Dr. Nirali U Patel, Dr. Viral M Bhanvadia, Dr. Hansa Goswami
Downloads: 1 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1
Research Paper, Pathology, India, Volume 12 Issue 9, September 2023
Pages: 740 - 744Intranasal Malignantmelanoma: Pathogenesis Epidemiology and Clinical Insight
Lakshita Rohilla, Karandeep Singh, Abhijit Garg
Downloads: 108 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1
Research Paper, Pathology, India, Volume 9 Issue 4, April 2020
Pages: 1270 - 1272Utility of Immunohistochemical Markers in the Diagnosis of Small Cell Neuroendocrine Carcinoma Cervix - A Case Report
Dr Kalaranjini K V, Dr Sheelavasudevan, Dr Limi Mohandas
Downloads: 119
Research Paper, Pathology, India, Volume 3 Issue 10, October 2014
Pages: 444 - 445Nasal Mass: Extramedullary plasmacytoma, A Rare Entity: Case Report
Bhushan Kathuria, Himani Dhingra