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Research Paper | Pharmaceutical Science | India | Volume 7 Issue 9, September 2018 | Rating: 7 / 10

Antidiabetic and Anti-Hyperlipidemic Potential of Linum usitatissimum (Linn.) Seeds in Streptozotacin Induced Diabetic Rat

M. D. Kitukale | A. V. Chandewar

Abstract: The present study was designed to evaluate the anti-diabetic and Anti-hyperlipidemic potential of Linum usitatissimum (Linn. ) seeds. The dried, crushed seeds were extracted successively by methanol and water. These extract then subjected for phytochemical screening. Animals were divided in seven groups and treated high dose (400 mg/kg) and low dose (200 mg/kg) of methanolic and aqueous extract and compared with diabetic control group. Results indicates that administration of methanolic and aqueous extract of Linum usitatissimum (Linn. ) seeds daily for 28 days showed significant decrease in the blood glucose, cholesterol, triglyceride, LDL and significant increase in HDL of the STZ induced diabetic rats compared to the diabetic control rats. The findings of this research suggest that the methanolic and aqueous extract of Linum usitatissimum (Linn. ) seeds may contains bioactive constituents with anti-diabetic potential which can be used for the treatment of diabetes mellitus and hyperlipidemia.

Keywords: Linum usitatissimum Linn, Diabetes, antidiabetic agents, Hyperlipidemia, Anti-hyperlipidemic agents, cholesterol, LDL

Edition: Volume 7 Issue 9, September 2018,

Pages: 369 - 373