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Research Paper | Chemistry | India | Volume 7 Issue 12, December 2018 | Rating: 6.5 / 10
Synthesis and in vitro Antibacterial Activity of Novel Substituted N-1, 3-Benzoxazol-2yl Benzene Sulfonamides
Gajanan Shanbhag | H. M. Vagdevi
Abstract: From many centuries human beings have been exposed to pathogens. In current modern medicine microbial infections are a major growing problem in which only a few antimicrobial agents are used in medical practice. Though several antimicrobial agents are currently available, there is a critical need for the development of new and specific antimicrobial agents. Amongst them benzoxazole derivatives constitute much importance in medicinal field due to their broad range of biological activity. Two novel N-1, 3-Benzoxazol-2yl benzene sulfonamides have been synthesized by cyclizing four different amino alcohols with Cyanogen bromide to get 1, 3-benzoxazol-2-amine which upon treating with substituted phenyl sulfonyl chlorides gave novel N-1, 3-Benzoxazol-2yl benzene sulfonamides. After structural confirmation, the title compounds were screened for their antimicrobial and anti oxidant activity. The obtained compounds were tested for antimicrobial activity against Staphylococcus aureus and Escherichia coli at 30ppm and 300ppm and subjected the same compound for molecular docking studies with respect to antimicrobial activity. Both the compounds 3a (N- (7-bromo-1, 3-benzoxazol-2yl) -4-methylbenzene-1-sulfonamide) and 3b (4- bromo-N- (7-methyl-1, 3-benzoxazol-2-yl) benzene-1-sulfonamide) showed pronounced antimicrobial activity.
Keywords: antibacterial activity, sulfonamides, benzoxazole
Edition: Volume 7 Issue 12, December 2018,
Pages: 715 - 717