Downloads: 136 | Views: 350 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper | Chemistry | India | Volume 8 Issue 6, June 2019 | Popularity: 6.3 / 10

Rate This Article!      

Preparation, Characterisation and In-Vitro Evaluation of Mercapto Analogue of Dihydropyrimidone Derivatives for their Antimicrobial, Anti-Arthitic and Thrombolytic Activity

S. R. Jagtap, R. D. Gaikwad, B. B. Bahule, R. P. Yadav

Abstract: In the present paper, we wish to report the synthesis of mercapto- dihydropyrimidone derivatives starting from readily available reactants, reagents and catalysts. We have successfully carried out the cyclocondensation reaction of aromatic aldehydes, thiourea and ethyl cyanoacetate in presence of sodium carbonate. Yields of these derivatives are high and the crude products can be purified either by column chromatography or recrystallisation techniques. Finally they were characterised by IR, PMR and CMR spectroscopy. The mercapto- dihydropyrimidones were tested positive for their antimicrobial activity. They were also found to exhibit invitro-anti-arthtic and thrombolytic activity.

Keywords: Mercapto-dihydropyrimidones, cyclocondensation, antimicrobial activity

Edition: Volume 8 Issue 6, June 2019

Pages: 1274 - 1276

Make Sure to Disable the Pop-Up Blocker of Web Browser

Click to Cite this Article

Similar Articles