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Research Paper | Pharmaceutical Science | India | Volume 8 Issue 9, September 2019 | Rating: 6.9 / 10

A Study on Formulation and Evaluation of Oral Dispersible Tablets - Propranolol HCL

D. Radhika

Abstract: The main objective of the present work is to develop oral disintegrating of tablets of Propranolol hydrochloride. This study was aimed, which can disintegrate or dissolve rapidly once placed in the oral cavity. Propranolol hydrochloride is a Antihypertensive drug, which undergoes extensive hepatic degradation (76 %), which have poor oral bioavailability for overcoming this problem oral disintegrating of tablets of Propranolol hydrochloride can be formulated which avoids extensive first pass metabolism and improvement in dissolution efficacy, disintegration time which results in improvement in bioavailability. The ODTs are prepared by direct compression technique. All the prepared formulations were subjected to various evaluation parameters like hardness, thickness, friability, weight variation, wetting time, water absorption ratio, in-vitro dispersion time, in-vitro disintegration, and in-vitro dissolution. The optimised formulation of F5 oral disintegrating tablets containing crosspovidone showed hardness of 4.2kg/cm2, thickness of 2.61mm, friability of 0.28 %, wetting time 45sec, water absorption ratio of 69 %, disintegration time of 22 sec, content uniformity of 20.28mg and in-vitro drug release of 97.4 % better than other formulations containing sodium starch glycolate and cross carmellose sodium. The advantage of this formulation is such that in case of hypertension attack patient can take the drug without the usage of water.

Keywords: Propranolol HCl, Super disintegrants, Oral disintegrating tablets, Disintegration time, Direct compression

Edition: Volume 8 Issue 9, September 2019,

Pages: 1527 - 1533