Downloads: 195 | Views: 367 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1
Research Paper | Medicine Science | Congo | Volume 8 Issue 12, December 2019 | Popularity: 7 / 10
Effect of Probiotic Yogurt Supplementation on Intestinal Inflammation and Oxidative Stress in HIV-Positive Patients on Antiretroviral Therapy: Randomized Controlled Trials in 24 and 48 Weeks
Kasamba Ilunga Eric, Balaka Ekwalanga Michel, Mulumba Kadiebwe David, Kalumba Kambote Athy, Ilunga Nikulu Julian, Lungu Anzwal, Kalenga Mwenze Kayamba Prosper, Malangu Mposhy Emmanuel Prosper
Abstract: Human immunodeficiency virus (HIV) infection and antiretroviral therapy (ART) have been associated with high oxidative stress in HIV patients. The disparity in antioxidant levels and secondary inflammation due to intestinal bacterial translocation in people living with HIV is the leading cause of morbidity and mortality associated with HIV infection. Using a simple 1: 1 randomization, Efavirens (EFV) and Lopinavir (LPV) -treated antiretroviral (ARV) -treated patients were additionally supplemented with probiotic yogurt and then followed for 48 weeks and evaluated at inclusion, at mid- and at the end of the course, by the determination of markers: immunological (CD4), virological (viral load), inflammatory (soluble Hs CRP, CD14 and CD163) and oxidative stress [Superoxide dismuthase (SOD, glutathione peroxidase (GPx) and Zinc]. The results confirm that HIV infection induces inflammation by a very significant increase in sCD14, sCD163 and HsCRP; and a collapse of the antioxidant protective system characterized by decreased levels of SOD, GPx, and Zinc. At weeks 24 and 48, a significant reversal of markers of inflammation and oxidative stress was observed under the ART + Probiotic Yogurt arm. Only the value of Zinc remained at a subnormal rate. All patients in the same arm had their undetected viral load since week 24. Although probiotic yogurt supplementation with ART has a significant impact on immunologic, virologic, inflammatory and oxidative stress markers compared to ARV only, it should be associated with Zinc for an optimal evolution of seropositive patients.
Keywords: HIV, Inflammation, Oxidative Stress Probiotic
Edition: Volume 8 Issue 12, December 2019
Pages: 365 - 373
Make Sure to Disable the Pop-Up Blocker of Web Browser
Similar Articles
Downloads: 0
Review Papers, Medicine Science, Brazil, Volume 11 Issue 11, November 2022
Pages: 1088 - 1092Revisiting the Roles of IL-17 in Colorectal Cancer
Larissa Volpini Cardoso, Gustavo Gabriel Zonaro, Barbara Nunes da Silva, Giulia Frederico, Vinicius Barbieri Lanfredi, Leandro Minatel Vidal de Negreiros, Sergio Luiz Pinheiro, Raquel Franco Leal, Giovanna Rosa Degasperi
Downloads: 3 | Weekly Hits: ⮙1 | Monthly Hits: ⮙2
Research Paper, Medicine Science, India, Volume 11 Issue 12, December 2022
Pages: 415 - 418Serum Levels of IL-1?IN Patients Presenting with Cardiac Dyspnoe and their Association with NYHA Functional Classification
Dr. Smita Deokar, Dr. Neelam Redkar, Dr. Prakash Relwani, Dr. Naina Dalvi
Downloads: 3 | Weekly Hits: ⮙2 | Monthly Hits: ⮙3
Case Studies, Medicine Science, India, Volume 13 Issue 5, May 2024
Pages: 914 - 917Aortitis in a Patient with Psoriatic Arthritis
Dr R N Tejaswini, Dr Vijaya Prasanna Parimi, Dr S Bhavana
Downloads: 50
M.Tech / M.E / PhD Thesis, Medicine Science, India, Volume 6 Issue 8, August 2017
Pages: 618 - 622Alcohol and Tobacco Use among the HIV/TB Co-Infected Individuals: A Case of Nepal
Bhim Bahadur Subba 'Phudong', Dr. Nirmal Rimal
Downloads: 84
Research Proposals or Synopsis, Medicine Science, Saudi Arabia, Volume 5 Issue 12, December 2016
Pages: 2052 - 2056Review of the Level of Awareness Towards Occupational Injury among Restorative Staff at Selected Dental Clinics, Saudi Arabia
Dr. Duaa Adil Sharaf Sharaf