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Research Paper | Medical Science | Libya | Volume 12 Issue 11, November 2023 | Popularity: 4.9 / 10

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The Effect of Growth Hormone on Thyroid Function during Treatment Children with Short Stature

Abdussalam Elshakmak, Murad Elmhabresh, Alia Alhsoni, Aisha Alaroah

Abstract: Objectives: to evaluate the effect of GH therapy on thyroid function and the frequency of hypothyroidism during GH therapy. Patients and methods: This is retrospective observational study of 120 children (62 male and 58 female) treated with rGH at Endocrine clinic in Benghazi children hospital (2002 - 2017), Study variables of all cases were evaluated as follows: age, sex, indication of GH, age at starting therapy, duration of treatment, height at initiation of GH therapy, height velocity in 1st year of therapy, height velocity in 2nd year of therapy. Results: This study shows that shifts in thyroid hormone levels are common during the first year of GH therapy in children who are initially euthyroid. Conclusion: GHD is the most common indication of GH therapy. All indications showed significant 1-year treatment response to therapy. Younger age at initiation of rGH therapy was independently associated with significant response to therapy suggesting the importance of identifying children with short stature and prompt initiation of GH therapy. Shifts in thyroid hormone levels are common during the first year of GH therapy in children who are initially euthyroid and post GH hypothyroidism is uncommon.

Keywords: growth hormone, short stature, hypothyroidism

Edition: Volume 12 Issue 11, November 2023

Pages: 747 - 754

DOI: https://www.doi.org/10.21275/ES231028140048

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