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Research Paper | Chemical Pathology | Nigeria | Volume 13 Issue 6, June 2024 | Rating: 5 / 10

Assessment of Serum Vitamin D in Patients with Hypothyroidism in a Nigerian Tertiary Hospital

Dalili M. S | Hadiru G. M | Dungus M. M | Aisha S. K | Amali A. O | Hassan A. A ^[2] | Gademi F. M | Fatima M. L | Halima M. A | Musa A. H | Mshelia D. S

Abstract: Introduction: Hypothyroidism is said to be associated with Vitamin D deficiency which is not routinely assessed in hypothyroid patients. The serum level of 1, 25 - dihydroxycholecalciferol and its link to hypothyroidism was assessed. Material and Methods: A total of 70 males and 90 females aged 20 - 60 years were assessed for the study. Evaluation of serum 1, 25 - dihydroxycholecalciferol was done on ELISA monobind Inc. CA 92630, immuno - assay analyzer. Serum fT3, fT4 and TSH were also evaluated by enzyme linked immunosorbent assay (ELISA) technique using stat - fax - 2100. Result: In our study, we have found the values of fT3 in the subjects as 1.21+ 0.89pg/ml lower than controls values of 1.92+0.66pg/ml, values of fT4 in subjects as 0.60+0.53ng/dl as compared to control group value of 1.40+0.30ng/dl, values of TSH as 2.07+1.19miU/L higher than the control group of 0.48+1.67 miU/L. The mean values of 1, 25 - dihydroxycholecalciferol for subjects as 25.80+4.20 nml/L lower than the control group with 35.70+6.30. Conclusion: Our study findings suggest that patients with hypothyroidism also have low serum levels of 1, 25 - dihydroxycholecalciferol (Vitamin D) which can have implications related to numerous organ systems, such as the Bones, Kidneys, Cardiovascular, and Immunological systems.

Keywords: fT3, fT4, TSH, 1, 25 - dihydroxycholecalciferol (Vitamin D), Hypothyroidism and Vitamin D deficiency

Edition: Volume 13 Issue 6, June 2024,

Pages: 575 - 578