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Review Papers | Anaesthesiology | India | Volume 11 Issue 11, November 2022 | Rating: 5 / 10

To Compare the Analgesic Effect of MgSO4 and Clonidine Added to Ropivacaine in Ultrasound-Guided Tap Block for Postoperative Analgesia in Patients Scheduled for Cesarean Section under Subarachnoid Block

Dr. Chethanananda .T .N | Dr. Sandhya Lakshmy Menon | Dr. Misabah Shahid

Abstract: Background and Aims:Transversus abdominis plane (TAP) block has proven to be an effective component of multimodal analgesic regimens for a variety of abdominal procedures. Magnesium sulphate (MgSO4) N-methyl-D-aspartate receptor antagonist and clonidine an alpha agonist have the potential to be an ideal adjuvant to local anaesthetic in TAP block. This study was designed to compare the efficacy of MgSO4 and clonidine as an adjuvant to Ropivacaine in TAP block in patients scheduled for caesarean section under subarachnoid block (SAB). Methods: Thirty pregnant women belonging to American Society of Anaesthesiologists physical status 2, aged between 20 and 40 years, scheduled for elective caesarean section under SAB were recruited. Patients in Group C (n = 15) received 20 mL 0.25% Ropivacaine with Clonidine 150mcg, whereas those in Group M (n = 15) received 20 mL 0.25% Ropivacaine with 150 mg) MgSO4 in the ultrasound (USG)-guided TAP block performed on each side after the completion of the surgery under SAB. They were evaluated for pain using VAS score at 0, 2, 4, 6,8, 12,14,18 and 24 h, time to first rescue analgesic and duration of postoperative analgesia were noted. Results: The post-operative visual analogue scale (VAS) scores were lower in both Groups till 14 hours following which clonidine group showed significantly better analgesia than magnesium group. Rescue analgesia was 20.17 + 3.42 hrs in group C which was more when compared with group M which was 13.07 + 2.12 hrs. Over all pain reduction was good and patient had better satisfaction. Conclusion: Addition of Clonidine as an adjuvant to Ropivacaine provides better prolongation of post-operative analgesia as compared to Magnesium sulphate, without any significant untoward effects.

Keywords: clonidine, magnesium sulphate, tap block, postoperative

Edition: Volume 11 Issue 11, November 2022,

Pages: 1419 - 1423