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Analysis Study Research Paper | Cardiology Science | India | Volume 12 Issue 10, October 2023 | Popularity: 5.3 / 10

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Correlation of Early WBC Count with Ejection Fraction in STEMI Patients: A Prospective Study

Thaha Mohamed Hussain, N Swaminathan

Abstract: Background: Elevated White Blood Cell Count (WBC-C) in the setting of acute myocardial infarction (AMI) has been linked to adverse cardiovascular outcomes. This study explores the relationship between WBC-C within the first 24 hours of chest pain onset and ejection fraction in ST-segment elevation myocardial infarction (STEMI) patients. Methods: A cohort of 49 STEMI patients presenting within 24 hours of symptom onset was enrolled. WBC count and ejection fraction were assessed immediately upon admission. Upon presentation, the white blood cell (WBC) count was promptly assessed using standard laboratory techniques. Simultaneously, echocardiography was performed to measure the ejection fraction, providing an immediate snapshot of cardiac function.Statistical analyses evaluated the correlation between ejection fraction and WBC count. Results: The cohort demonstrated diverse age distribution, with the majority falling within the 41?60-year range. Males constituted the majority with 35 participants (71.4%), while females accounted for 14 participants (28.6%). Ejection fraction varied across three categories: <40%, 41-50%, and 51-60%. Anterior Wall Myocardial Infarction (AWMI) was identified in 53.1%, while 46.9% presented with Inferior Wall Myocardial Infarction (IWMI). A significant negative correlation emerged between ejection fraction and WBC count (Pearson Correlation = -0.462, p-value = 0.001). Conclusion: This study uncovers a significant link between early WBC count and ejection fraction in STEMI patients. Lower ejection fractions align with higher WBC counts, indicating heightened inflammation. These findings inform risk assessment and tailored treatments. Further research is needed for broader clinical application and mechanistic insights.

Keywords: STEMI, WBC count, Myocardial infarction, Leukocyte, Inflammation, Ejection fraction

Edition: Volume 12 Issue 10, October 2023

Pages: 494 - 497

DOI: https://www.doi.org/10.21275/MR231005125413

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